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Symbol Name ID |
Tdp1
tyrosyl-DNA phosphodiesterase 1 MGI:1920036 |
| Darker colors indicate more annotations |
| Human Phenotypes | Spastic dysarthria |
Decreased number of peripheral myelinated nerve fibers |
Peripheral axonal neuropathy |
Cerebral atrophy |
Cerebellar vermis atrophy |
Cerebellar atrophy |
Global brain atrophy |
Spinocerebellar tract degeneration |
Ataxia |
Decreased motor nerve conduction velocity |
Dysarthria |
Intellectual disability |
Areflexia |
Steppage gait |
Peripheral neuropathy |
Sensorimotor neuropathy |
Sensory neuropathy |
Seizure |
Pain insensitivity |
Distal sensory impairment |
Impaired distal proprioception |
Impaired vibratory sensation |
Impaired vibration sensation in the lower limbs |
| Disease(s) Associated with TDP1 | |||||||||||||||||||||||
| spinocerebellar ataxia with axonal neuropathy 1 |
| Mouse Phenotypes | small cerebellum |
abnormal neuron physiology |
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| Availability | Mouse Genotype | ||
| Tdp1Gt(XD105)Byg/Tdp1Gt(XD105)Byg | |||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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